Miconazole nitrate is a synthetic imidazole derivative with a pronounced antifungal activity and a potent activity against Gram-positive bacteria. Polymyxin B sulphate is a polypeptide antibiotic with bactericidal activity against Gram-negative bacteria. Prednisolone acetate is a glucocorticoid with strong anti-inflammatory and antipruriginous activity.

Miconazole selectively inhibits the synthesis of ergosterol, which is an essential component of the membrane of yeasts and fungi. Pollymyxin B binds to phospholipids in the cytoplasmic membrane, whereby the membrane permeability is disturbed. This results in lysis of the bacteria. The anti-inflammatory action of prednisolone acetate results from its reduction of the permeability of capillaries and vascular proliferation and from the inhibition of the fibroblast action. Membranes of the liposomes are stabilized against hypoxia, toxins etc.

Numerous experiments in laboratory animals and in man have demonstrated that:

• After topical application of miconazole nitrate virtually no systemic absorption of miconazole from the skin or mucous membranes takes place.
• Absorption of polymyxin B via the skin, mucosae, burn wounds and other wounds is negligible.
• Systemic absorption of prednisolone on normal or abraded skin is minimal. The barrier to absorption appears to be located at the dermo-epithelial junction with longterm depot formation in the upper epidermal layers without any significant systemic absorption.

Composition (per ml)

Miconazole Nitrate        …… 23 mg

Polymyxin B Sulphate   …… 5500 IU (=0.696 mg)

Prednisolone acetate     …… 5 mg

Indications for use

Surolan is used in dogs and cats for the therapeutic treatment of otitis externa and dermatitis caused by:

Yeasts and fungi:

• Microsporum spp.
• Trichophyton spp.
• Candida spp.
• Malassezia pachydermatis

Gram-positive bacteria :

• Staphylococcus spp. (sensitive strains)
• Streptococcus spp. (sensitive strains)

Grame-negative bacteria :

• Pseudomona spp. (sensitive strains)
• Escherichia coli

Earmites :

• Otodectes cynotis

Surolan also has anti-inflammatory and anti-pruritic activity.

Contra-indications

Not to be used in animals with perforated ear-drums since polymyxin B is known to be a potential ototoxic agent.

Dosage and Administration

Ears: After cleaning the acoustic meatus, apply Surolan and ensure an adequate distribution of the preparation, by massaging the ear base. Apply 3-5 drops of Surolan into the ear twice daily.

Skin: Ensure the wound is well covered with Surolan and rub into the wound with a gloved hand. Apply Surolan to the affected areas twice daily.

Shake well before use.

The hair around and on the lesions should be clipped at the start of treatment and again during treatment, if necessary.

Do Not Swallow

Prescription Only Medicine

For Animal Treatment Only